GEF-effector interactions
نویسندگان
چکیده
منابع مشابه
GEF-effector interactions
Members of the Arf family of small GTP-binding proteins, or GTPases, are activated by guanine nucleotide exchange factors (GEFs) that catalyze GDP release from their substrate Arf, allowing GTP to bind. In the secretory pathway, Arf1 is first activated by GBF1 at the cis-Golgi, then by BIG1 and BIG2 at the trans-Golgi and trans-Golgi network (TGN). Upon activation, Arf1-GTP interacts with effec...
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Program in Molecular, Cell, and Developmental Biology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA; Institute of Experimental and Clinical Pharmacology, Medical Faculty Mannheim, University of Heidelberg, D-68169 Mannheim, Germany; Department of Biology, Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah 84112, USA; Department of Pharmacology,...
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Vacuolar protein sorting 9 (VPS9)-ankyrin-repeat protein (Varp) has recently been identified as an effector molecule for two small GTPases-Rab32 and Rab38-in the transport of a melanogenic enzyme tyrosinase-related protein 1 (Tyrp1) to melanosomes in melanocytes. Although Varp contains a Rab21-guanine nucleotide exchange factor (GEF) domain (i.e., VPS9 domain), since Rab21-GEF activity is not r...
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ژورنال
عنوان ژورنال: Cellular Logistics
سال: 2014
ISSN: 2159-2799
DOI: 10.4161/21592780.2014.943616